Outcomes of Propofol or Thiopental Sodium and Oral Midazolam as an Induction Agent for Day Care Surgery


  • Maryam Saleem, Usman Zeeshan, Dur I Shahwar, Madiha Zafar, Umar Iqbal




Background: The increasing popularity of outpatient surgery has prompted the search for new anesthetic agent that can provide safe and effective anesthesia with a rapid and smooth recovery. Day care surgical procedure is extensively accepted and has been attaining recognition for over a time. The cost effectiveness and early recovery are an essential part of day-care surgical treatment in evolving countries.

Aim: To compare the recovery score and cost-effectiveness after oral induction of midazolam and thiopental sodium with propofol alone in day-care surgical procedure.

Methods: Eighty patients were selected, 40 in each ASA grade I and II group. In A group; patients were administered propofol at dose of 2 mg / kg for induction, and in group B; 0 2.5 mg / kg thiopental sodium and 0.25 mg / kg midazolam orally were given 30-mints prior to induction. Perioperative heart rate, time to ready to go home, blood pressure and recovery score were observed. The average induction cost was determined in group A and B.

Results: After 30 minutes of reversal, the score of recovery in groups A and B were 8.90 ± 1.82 and 8.02 ± 1.01, correspondingly. The group B has significantly lesser cost (PKR 90.25±10.73) in comparison to the group A (PKR 700.0 ± 100.0) (p <0.05).

Conclusions: Preoperative induction of oral midazolam and low doses of thiopental sodium is comparatively cost effective compared to induction of propofol in day-care surgical procedure.

Keywords: Oral midazolam, Day care surgery, Propofol and Thiopental sodium.