Comparison of Efficacy of Injectable V/S Oral Vitamin D (Cholecalciferol) for the Treatment of Rickets Among Children

Abstract

Objective: The purpose of this study is to evaluate the effectiveness of vitamin D (cholecalciferol) injections against vitamin D taken orally in the treatment of rickets in children.

Methodology: One hundred patients were chosen at random from the outdoor paediatrics department of Madina Teaching Hospital, Faisalabad, during December 2021 to June 2022 and assigned to receive either oral vitamin D 600,000 IU in three doses on the same day or intramuscular vitamin D 600,000 IU. Vitamin D and x-rays were taken as a baseline. At the 30-day mark, we checked in with every one of the kids again. Children were examined clinically, biochemically, and radiographically, and their results were documented during the subsequent checkup. Pre- and post-treatment increases in blood levels of vitamin D were compared across all groups. Keeping the blood vitamin D level at >20ng/ml at the 30-day follow-up indicated a successful course of therapy.

Results: Our research comparing the effectiveness of injectable vitamin D (Cholecalciferol) and oral vitamin D for the treatment of rickets in children found that 74.29% (n=52) in Group-A and 88.57% (n=62) in Group-B were successfully treated; the p value for this comparison was 0.02.

Conclusion: We found that when comparing injectable vitamin D (cholecalciferol) to oral vitamin D for treating rickets in children, the former was much more successful.

Keywords: Children, Rickets, Vitamin D, injectable, oral, efficacy