Evaluation of the Role of Vaspin and Insulin Resistance in Metabolic Syndrome

Abstract

Background: At least three of the following five medical factors must be present in order for someone to be diagnosed with metabolic syndrome. These conditions include abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). There is a correlation between having metabolic syndrome and having an increased risk of getting cardiovascular disease and type 2 diabetes. The percentage of older people who are members of racial and ethnic minority groups is growing at an alarming rate. Insulin resistance, metabolic syndrome, and prediabetes are conditions that are intricately connected to one another and share characteristics in common. It is believed that the condition is caused by an underlying disease of energy use and storage called MetS, which is closely related to the already existing weight gain, also known as obesity, and sloth. The blood levels of vaspin, insulin, and the HOMA IR value all increase as a result of this, and the levels of a number of other parameters also change as a result.

Patients and methods: A case control study was conducted in the form of a comparison between individuals who went to the consulting clinic for internal diseases during the study period, which lasted from December 2021 to February 2022. There were a total of 60 confirmed cases with metabolic syndrome and 30 healthy people, and their ages ranged from 24 to 67. Patients from the Salah El-Din Governorate and the surrounding areas had their insulin and vaspin levels tested using the Elisa instrument. Patients with metabolic syndrome were classified as having the condition based on their fasting blood glucose levels, triglyceride levels, HDL-C levels, systolic blood pressure, and waist circumference. This information was obtained from an organization affiliated with the International Diabetes Federation.

The results: The following findings emerged from the research conducted, and it was discovered that the level of vaspin and the HOMA IR value were significantly higher in individuals diagnosed with metabolic syndrome as compared to healthy people. And a negative correlation with HDL-C, a positive correlation between vaspin, HOMA IR, and insulin levels, as well as a positive correlation with the level of fasting glucose; moreover, HOMA IR value was significantly higher in patients with the metabolic syndrome than in the controls without the metabolic syndrome.

Keywords: metabolic syndrome, insulin resistance, and vaspin