Compare the Efficacy of Aspartate Aminotransferase to Platelet Index (APRI) and FIB-4 with Transient Elastography: FibroScan in Patients with Chronic Hepatitis C

Abstract

Objective: Compare the efficacy of aspartate aminotransferase in patients with chronic hepatitis with fibro scan to platelet index and FIB-4 with transient elastography.

Study Design: Cross-sectional study.

Place & Duration of Study: Department of Medicine, Azhra Naheed Medical College, Lahore from 1^st May 2020 to 31^st October 2020.

Methodology: Eleven hundred and fifty patients of both sexes were enrolled. Demographic patients after written consent have been registered. Both patients had a detailed history, clinical review and investigations designed to rule out misunderstanding and partiality in the findings of the research. The diagnosis was perfectly performed for continuing hepatitis C infection, which included various biochemical tests. We contrasted the efficiency of the readily available aspartate aminotrasnferase with the FIB-4 with fibro scansand platelet index for distinguishing progression of hepatitis C virus fibrosis.

Results: Mean age of the patients was 39.14±14.68 years with mean BMI 22.68±9.14kg/m². Seven hundred and thirty (63.5%) were females and 420 (36.5%) were males. Almost 70% of the HCV patients were on stage F0-F1 and 6.5% of the patients were in F2 stage and 15.7%, 16.97% of the patients were in F3 and F4. No significant difference was observed regarding mortality rate with p value <0.05.

Conclusion: Aspartate aminotransferase/platelet index and FIB4 are expected to reliably separate cirrhotic and non-cirrhotic stages from the expensive and unusual fibro scan rating of HCV infected patients.

Keywords: Hepatitis C, Fibrosis, Liver, Aspartate aminostransferase (AST)