Frequency of Ethnicity and Causative Factors of Hepatocellular Carcinoma

Authors

  • Abdul Ghani Rahimoon, Sajan Sawai, Hira Laghari, Nand Lal Seerani, Zaheer Hussain Memon, Shabana Lakho

DOI:

https://doi.org/10.53350/pjmhs221651543

Abstract

Objective: To determine the frequency of ethnicity and other etiological factors of hepatocellular carcinoma.

Methodology: This cross-sectional study was conducted at the Liaquat University Hospital Hyderabad, Department of gastroenterology. The study occurred from March 2018 to February 2019 for a total period of one year. All the patients diagnosed as the cases of hepatocellular carcinoma; age more than 20 years of both genders were included. All the patients were assessed regarding their ethnicity and risk factors of hepatocellular carcinoma. A self-made study proforma was used for the data collection and data was analyzed by using the SPSS version 26.  

Results: A total of 80 patients of hepatocellular carcinoma were studied, their average age was 53.12+9.69 years, average CLD known duration was 05.40+3.90 years and the average known duration of HCC was 01.17+0.79 years. Males were in majority 76.3% and 40.0% of the cases had advanced disease. According to the ethnicity of the cases, Sindhi patients were 70.0%, followed by 6.3% were Punjabi, 1.3% were Pathan, 7.5% were Baloch and 15.0% were others. HCV was the most common cause 83.8%, 7.5% cases had HBV, followed by 2 cases had HBV+HDV and one case had HCV and HBV co-infection, while four cases were NBNC HCC patients. Tumor stage was statistically insignificant according to ethnicity (p-0.495).

Conclusion: Sindhi and Punjabi population was observed to be mostly affected and HCV was concluded the most common causative factor of hepatocellular carcinoma. 

Keywords: Ethnicity, causes, HCC

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How to Cite

Abdul Ghani Rahimoon, Sajan Sawai, Hira Laghari, Nand Lal Seerani, Zaheer Hussain Memon, Shabana Lakho. (2022). Frequency of Ethnicity and Causative Factors of Hepatocellular Carcinoma. Pakistan Journal of Medical & Health Sciences, 16(05), 1543. https://doi.org/10.53350/pjmhs221651543