Evaluate the Difference in three areas of Hypertension: Diagnostic Threshold, Staging, Therapy, and Goal of Blood Pressure Guidelines


  • Syeda Tasneem Kausar, Rubina Jabeen




Hypertension, Threshold, Staging, Blood pressure and Guidelines.


Background: Hypertension is main highest source of global illness proportion, impacting approximately 2.38 billion individuals worldwide. Although treatment guidelines can help with the appropriate care of this frequent illness, there are differences amongst clinical practice guidelines (CPGs), the amount of which is uncertain. Assessing the discrepancies in CPG recommendations across socioeconomic levels should help explain several of the worldwide variances in patient outcomes associated with hypertension.

Objective: The objective of study is to examine the worldwide variance in hypertension CPGs. It intends to evaluate variance in 3 areas: diagnosis criterion, staging, therapy and targeted BP guidelines in hypertension.

Methods: From July 2020 to June 2021, the MEDLINE database has been searched for national and international hypertension CPGs. An extra country-precise grey-literature search remained performed for altogether World Bank-identified nations and territories. Information from CPGs have been retrieved to describe the assessment, staging, therapy, and goal blood pressure, and changes across CPGs for all these areas have been examined.

Results: For the assessment, 48 CPGs from all World Bank-given situations and the implications were chosen. Ninety-six percent of recommendations classified hypertension as the hospital-based BP of 145/95 mmHg, and 89 percent suggested a goal blood pressure of 140/90 mmHg. Nine dissimilar first-step, 18 dissimilar second-step, also seven distinct third-step medication suggestions have been found in pharmacological therapy of hypertension. In the first-step therapy, low-income nations preferred diuretics (65%), whereas high-income countries provided greater options among antihypertensive categories. At BP 166/110 mmHg or higher, 44% of recommendations, including 72% from higher-income environments, suggested starting therapy with double treatment.

Conclusion: According to the result of this research, CPGs were substantially similar in diagnosis, staging, in addition target BP guidelines for hypertension. Clinical guidelines differed greatly, especially for second-line treatment. There was heterogeneity across economic levels; low-income nations administered cheaper pharmaceuticals, provided fewer prescription options to clinicians, and launched dual treatment later than higher-income ones. Future studies into the true reasons for this heterogeneity may enhance results for hypertension customers in a variety of therapeutic settings.