Post Oeprative Sore Throat (POST), Comparison Between Nebulization with Ketamine and Placebo

Authors

  • Rifah Zia, Shahid Iqbal, Mohammad Baqir Ali Khan, Muhammad Muazzam Butt, Tahir Nazeer, Muhammad Zahid Hanif

DOI:

https://doi.org/10.53350/pjmhs221651036

Keywords:

POST, Ketamine, Placebo, nebulized ketamine.

Abstract

Objective: To compare the frequency of post-operative sore throat with nebulized ketamine versus nebulized placebo pre- operatively in patients undergoing elective surgery under general anaesthesia.

Study design; Randomized Controlled trial.

Setting; Department of Anesthesia, Hameed Latif Hospital, Lahore.

Duration of study; 08-05-2018 to 08-11-2018.

Methodology: In this study, the cases of either gender and age range of 18 to 40 years undergoing elective surgery under GA requiring endotracheal tube were selected. The cases in Group A were nebulized with Ketamine (50 mg) mixed with normal saline while those in group B with normal saline only for 15 minutes. They were assessed at 4 hours on the basis of verbal response scale (VRS) after extubation regarding cough and irritation in the throat and score of 4 or more on VRS was labelled as POST.

Results: In this study out of 40 cases in each group males were 23 (57.5%) vs 26 (65%) and mean age was 34.21±4.21 vs 32.57±4.67 years in group A and B respectively. Post operative sore throat was seen in 8 (17.5%) in group A and 18 (45%) in group B with p= 0.01. This difference was significant in terms of female gender where this was seen more in females in group B 64.28% vs 11.76% (p= 0.001). This difference was also significant in cases with duration of surgery more than 60 minutes where it was seen in 14.28% vs 44.34% in group A and B respectively (p= 0.01)

Conclusion; Ketamine nebulization is significantly better for POST than placebo and this difference is also significantly high in terms of female gender and duration of surgery > 60 minutes.

Keywords; 

Downloads

How to Cite

Rifah Zia, Shahid Iqbal, Mohammad Baqir Ali Khan, Muhammad Muazzam Butt, Tahir Nazeer, Muhammad Zahid Hanif. (2022). Post Oeprative Sore Throat (POST), Comparison Between Nebulization with Ketamine and Placebo. Pakistan Journal of Medical & Health Sciences, 16(05), 1036. https://doi.org/10.53350/pjmhs221651036