Seroprevalence of Helicobacter Pylori in Plaque Psoriasis at Tertiary Care Hospital

Abstract

Background: Psoriasis is a common, chronic inflammatory skin disorder whose aetiology is largely unknown. Several microorganisms, including Helicobacter pylori, have been identified as triggering factors for the disease.

Aims: To determine the frequency of seroprevalence of Helicobacter pylori in chronic plaque psoriasis and to determine any relationship between sero-positivity to H. pylori and severity of chronic plaque psoriasis.

Study design: Cross-sectional study

Place and duration of study: Department of Dermatology, Pakistan Emirates Military Hospital, Rawalpindi from 1^st September 2020 to 31^st March 2021.

Methods: Eighty three patients of chronic plaque psoriasis were enrolled. Psoriasis Area Severity Index was calculated in each patient to determine the severity of psoriasis. Seroprevalence was confirmed by IgG anti H. pylori antibody in sera detected by enzyme linked immunosorbent assay.

Results: Mean age was 46.67±15.32 years. Majority of the patients, 46(55.42%) were between 46 to 70 years of age. Sixty three (75.90%) were males and 20(24.10%) were females. Sixty four (77.11%) of the patients showed sero-positivity to underlying helicobacter pylori infection. Frequency of seroprevalence of Helicobacter pylori increased with severity of plaque psoriasis (p=0.0001).

Conclusion: Chronic plaque psoriasis is associated with high frequency of H. pylori infection and statistically significant correlation was found between severity of psoriasis and underlying H. pylori infection.