Bleeding Disorders among women Presenting with Menorrhagia at Tertiary Care Hospital
Muhammad Sarwar Khan, Kiran Aamir, Aamir Ramzan, Aasma Naz, Khalil Ahmed Memon, Irfan Ahmed
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ABSTRACT
Objective: To study the spectrum of bleeding disorders among women, presenting to the study
setting with complaints of menorrhagia.
Methodology: This observational cross-sectional study was
conducted up on 121 women, during a period of 6 months, who were approached via
non-probability, consecutive sampling, presenting to the Dept. of Gyneacology
& Pathology – Liaquat University Hospital, Hyderabad with menorrhagia. Data
obtained from patient interviews and laboratory investigations were recorded
into a self-structured questionnaire after taking written informed consent. The
data obtained was analyzed using SPSS v. 21.0.
Results: The mean age of the women was 28.13 years (±5.21 SD). Among the underlying hemostatic
pathologies, VWD was the most common i.e. 21 (65.6%), followed by other
platelet dysfunctions (Glanzman Thrombasthenia (n=5, 15.6%) and Berard Soulier
Syndrome i.e. n=3, 9.4%) comprised the second most common finding. A cause of
hemostatic pathology among a minority of patients remained unidentified i.e.
n=3 (9.4%).
Conclusion: Keeping in view of hemostatic defects, the
study concludes that VWD is the commonest bleeding disorder among women
presenting with menorrhagia. A routine screening of females with menorrhagia on
their initial contact with the hospital can save years of suffering and lead to
early management and probable recovery.
Keywords: Von Willebrand Disease, Hemostatic Dysfunction, Bleeding Disorders, Platelet
Dysfunction, Menorrhagia & Bleeding Complaints among Women