Aim: To assess the pattern of firearm injuries and different effecting factors based on gender in Hyderabad, Sindh, Pakistan. Study Design: Retrospective and descriptive Place and duration of study: Depart. Forensic Medicine & Toxicology, BMC LUMHS Jamshoro 01-01-2017 to 31-12-2019. Methodology: Three hundred and nineteen autopsies based on purposive sampling method were revealed the death due to firearm injuries. The demographic information, pattern of death due to firearm and which part of body involved based on variables. Results: There were 267 males and 52 were females and 95 firearm autopsies were between 31 to 40 years. It was revealed that in 38 autopsies, head was involved, 78 autopsies chest was involved, 76 autopsies abdomen was involved while 267 were from homicidal. Moreover, the cause of death due to firearm in maximum patients was hemorrhage followed by septicemia in 106 autopsies. According to gender wise, 38 autopsies involved head part 30 were male and 8 were female, 78 autopsies involved chest part 65 were male and 13 were female, 76 autopsies involved abdomen part 66 were male and 10 were female. Conclusion: The high impact on the health care setups of country, which needs the immediate attention. The firearm injuries have an impact on young and older adult population. Key words: Firearm injury, Gender, Age