ABSTRACT

Objective: To investigate the serum albumin levels among hospitalized patients of chronic Liver disease (CLD) having SBP in Asian Institute of Medical Sciences Hospital Hyderabad, detecting early can potentially reduce its outcome of In-Hospital Mortality.

Methodology: The descriptive case series study was conducted from January 2019 to June 2019 at Gastroenterology ward of Asian Institute of Medical Sciences, Hyderabad. All cases of CLD having spontaneous bacterial peritonitis and either of gender were enrolled in the study. Cirrhosis stages were assessed by CTP (Child-Turcot-Pugh) score and MELD (Model for End-stage Liver Disease) score. Serum levels of albumin were taken under the supervision of well-trained staff nurse(s) by following all guideline protocols and taking care of every risk factor and error for minimizing the bias results. The data was analyzed using SPSS version 20.

Results: Mean age of the patients was 47.56±13.069 years. sampled serum albumin levels were found less than 2.0mg/dl have much higher in-hospital mortality rate compared to those having serum albumin levels more than 3.0mg/dl. There were also significant differences in outcome (in-hospital mortality) seen among the gender groups: Male vs. female; in-hospital death 42/165 vs. 19/58 (p-0.283). Hospital mortality was significantly high in CTP-C patients compared to CTP-B patients (59/185 vs. 02/38, (p-0.001). Early detection of high-risk patients is critical for better prognosis.

Conclusion: It was observed that, there is a high prevalence of cirrhosis and its complications and a significant relationship of in-hospital mortality among patients of SBP and their SAAG (serum Albumin ratios), which clearly signifies that those patients who have serum Albumin ratio lesser than 2.0mg/dl have higher in-hospital mortality as compared to those have serum Albumin ratio lesser than 2.1-3.1mg/dl and more than 3.0mg/dl.

Keywords: Cirrhosis, Albumin, Mortality