Abstract

Background: Uncontrolled diabetes mellitus (DM) may induce inflammation and the likelihood of bone fracture. The accumulation of final products from glycation and oxidative stress may cause changes in bone strength, metabolism and structure. Poor glycemic control may alter the calcium homeostasis, parathyroid hormone (PTH) and vitamin D secretion.

Aim: To evaluate the differences between iPTH, 25(OH)D and Ca ion levels as factors that affect on bone metabolism in controlled and uncontrolled DM groups.

Method: A cross-sectional study was conducted on 69 patients with DM in Diponegoro National Hospital. All patients were devided into two groups based on HbA1c levels. Intact parathyroid hormone (iPTH) and 25(OH)D levels were measured with enzyme-linked immunoassay (ELISA), while calcium (Ca) ion was measured with an ion selective electrode (ISE). T test and Mann-Whitney test were applied for data analysis and p<0.05 was considered as statistically significant.

Results: There were differences in iPTH level (p=0.031) and Ca ions (p=0.033) between group with controlled and that with uncontrolled DM, but there was no difference in 25(OH)D level (p=0.051) between both groups.

Conclusion: There were difference in iPTH anda Ca ion levels between both groups. Both iPH and Ca ion might impact on theurapeutic monitoring in patients with DM.

Keywords: Diabetes mellitus, parathyroid hormone, iPTH, 25(OH)D, Ca ion