Abstract

Aim: To compare the analgesic efficacy of two different doses of oral ibuprofen in patients with acute pain presented to emergency department.

Study Design: Randomized Controlled Trial

Place and Duration:Study was conducted in medicine department of Sheikh Zayed Hospital, Rahim Yar Khan for duration of six months from 1st October 2019 to 31st March 2020.

Methods: Two hundred and forty four patients of both genders with acute pain were enrolled in this study. Patient’s ages were 18 to 60 years. Patients were divided into two equal groups. Group A consist of 122 patients and received 400mg ibuprofen and group B with 122 patients received 800 mg ibuprofen orally. Pain scores were analyzed byusing visual analogue scale at 1, 4, and 8 hours after medication. Data was analyzed by SPSS 24.0.

Results: Mean age in group A was28.56±6.47 years and in group B it was 27.54±7.25 years.No significant difference was observed regarding pain by VAS between both groups at1, 4,and 8 hours. Significant reduction was observed at 1,4,and 8 hours.No significant difference was observed regarding side effects such asdizziness, nausea, and vomiting between both groups. Patient’s satisfaction rate was comparable between both groups.

Conclusion: Oral ibuprofen 400mg and 800mg both are effective in reduction of acute pain. No significant difference was observed regarding side effects of both groups.

Keywords: Emergency Department, Acute Pain, Ibuprofen, VAS.