Circulating Expressions of Gonadotropin Releasing Hormones and Risk of Ovarian Cancer
Gulshan Parveen, Ali Hassan, Muhammad Hassam Rehm, Awais Altaf, Nureen Zahra, Arif Malik, Anam Naz, Huma Sattar
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ABSTRACT
Background: Ovarian cancer (OC) is
a worst type of malignancy in the field of gynecology. This is because ovarian
tumors diagnosed at advanced stage of disease. The exact mechanism for its
development is still unknown.
Aim: The aim of this study is to measure the
levels of steroidal hormones and their function in ovarian cancer progression.
Methods: In the present study,
fifty ovarian cancer patients and fifty control individuals were taken and
serum was separated from their blood samples. The levels of steroid hormones were measured by ELISA kit methods.
Results: Result of the current
study determined the levels of E2, progesterone, testosterone, FSH,
LH, 17-β-HSD-I, 17-β-HSD-II, cortisol and aromatase were extensively higher in
patient group in comparison with healthy individuals.
Conclusion: Current study
concluded the Study concluded that overexpression of steroid hormones may lead
to enhance tumor survival in ovarian cancer through various signaling
mechanisms.
Keywords: Ovarian cancer, Estradiol, FSH, LH,
progesterone