Aim: To compare and evaluate clinical efficacy of corticosteroids in thrombocytopenia in patients suffering from moderate to severe Dengue.

Methods:  This randomized single blinded study was conducted at Furqan Clinic Gulbahar Peshawar from August 2021 to October 2021. 100 individuals of ages between 20 to 60 years irrespective of  gender, with positive NS1 antigen test and no co-morbidities were included in study by convenient sampling technique. Patients with dengue and  Covid-19 were excluded  from the study. Randomization was done in four treatment groups.  Consent was taken from all patients prior treatment with Cefixime, artemether/lumefantrine, IV Dexamethasone in adjunct to oral papaya leaf extracts. Duration of study was 3 months.  Statistical analysis done using SPSS software version 24.

Results: Group C and D showed the significant increase in platelet count as compared to group A and B. Pronounced effect was observed in group D.

Conclusion: Intravenous Dexamethasone produced more beneficial effects in adjunct to oral carica papaya leaf extracts on thrombocytopenia with reduced risk of bleeding.

Keywords: Artemether, carica papaya leaf , Dexamethasone, Lumefantrine, platelet count