Background: Hypomagnesaemia is related with diabetes mellitus (DM) and its complications and insulin resistance. On the other hand, the patients of Diabetes mellitus have decreased levels of magnesium. This analysis was planned to assess levels of serum magnesium in patients with newly diagnosedimpaired glucose intolerance and the severity of intolerance e.g., DM or impaired glucose tolerance, impaired fasting glucoseand compare the serum levels of magnesiumwith sex and age matched healthy individuals.

Methods: This case-control study was carried out in the Outpatient department of Diabetes Hospital Peshawar and CMH Multan Institute of Medical Science Multanfor six months duration from February 2020 to July 2020. New patients of glucose intolerance (IGT 2, DM 54) were matched with same number of sex and age matched healthy subjects (n=56). All participants in the study done with the level of serum magnesium and comparisons were made between the case and the healthy subjects.

Results: This study evaluated 56 patients (studied group) and 56 healthy volunteers of similar gender and age (control group) with glucose intolerance.There was no substantial difference between the control group in terms of sex, body mass index (p = 0.39) and age (p = 0.88). The level of serum magnesium was according to standard in 30 patients and 39 healthy subjects, and decrease in 26 patients and 17 normal subjects. The mean concentration of serum magnesium was lower in the experimental group (0.69±0.16m. Mol / L) than in the control group (0.84±0.17 m. Mol / L), though the variance was not substantial (p = 0.37).

Conclusions: The levels of Serum magnesium were lesser in individuals with IGT and DM compared to healthy volunteers of the same sex and age and levels of serum magnesium were related to blood glucose levels.

Key words: Serum magnesium, Diabetes mellitus, Glucose intolerance, Impaired glucose tolerance, Impaired fasting glucose.