ABSTRACT

Aim: To determine the effectiveness of ondansetron with prochlorperazine in preventing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

Study design: Randomized controlled trial.

Place and duration of study: Department of Anaesthesia, Shalamar Medical & Dental College Lahore from 1st January 2020 to 30th June 2020.

Methodology: One hundred and twenty six patients of both genders with ages 20 to 70 years undergoing laparoscopic cholecystectomy were enrolled in this study. Patients were divided into two groups; group I and group II. And each group contains 63 patients. Group I received ondansetron and group II received prochlorperazine before induction of anesthesia.

Results: No significant difference was observed between both groups regarding age, gender, body mass index and ASA class with p-value >0.05. In group I 8(12.7%) patients had nausea and 11(19.05%) had vomiting while in group II 10(15.9%) patients had nausea and 7(11.11%) patients had vomiting, no significant difference was observed between both groups I and II with p-value >0.05. In group I, 9(14.3%) patients had adverse effects while in group II, 13 (20.63%) patients had side effects of medication such as headache, dizziness and sedation. No significant difference was observed regarding anti-emetics use between both groups (p value >0.05).

Conclusion: Ondansetron and prochlorperazine both are safe and effective for preventing postoperative nausea and vomiting with fewer rates of side effects in patients undergoing laparoscopic cholecystectomy.

Keywords: Odansetron, Prochlorperazine, Laparoscopic Surgery, Nausea, Vomiting