ABSTRACT

Background: Ovarian cancer is a leading cause of death from gynecologic malignancies. The diagnosis of ovarian cancer is confirmed by examination of a biopsy usually removed during surgery.

Aim: To determine the diagnostic accuracy of risk of malignancy index (RMI) in patients undergoing open surgery for ovarian mass taking histopathology as gold standard.

Study design: Cross-sectional study.

Methodology: Patients (n=75) having were enrolled to conduct the present study at Department of Department of Obstetrics & Gynaecology, Jinnah Hospital Lahore-Pakistan for 6 months. Enrolled patients were informed and consent was taken. The collected data was analyzed statistically by using SPSS version 20. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of RMI was calculated by using 2X2 table taking histopathology as gold standard.

Results: The mean age of the patient was 43.87±11.539 years. The mean RMI of the patient was 201.81±148.939. The calculated sensitivity and specificity of RMI were 86.2% and 91.3% respectively. The calculated positive & negative predictive values of RMI were 86.2% and 91.3% respectively. The overall diagnostic accuracy of RMI was 89.3%.

Conclusion: RMI is accurate enough to differentiate malignant and benign ovarian masses that we can rely on RMI in future.

Keywords: Risk of Malignancy Index, Ovarian Masses, Malignant Tumor and Histopathology