ABSTRACT

Objectives: To compare efficacy and tolerability of Ondansetron versus Metoclopramide in the treatment of Hyperemesis Gravidarum.

Study Design: Randomized controlled trial

Place and Duration: Department of Obstetrics &Gynaecology Unit- II, Holy Family Hospital, Rawalpindi for duration of six months from August 2015 to January 2016.

Methodology: A total of 230 pregnant ladies (<16 weeks of gestational age) with hyperemesis gravidarum, 18 to 40 years of age were included. Patients with pre-existing medical condition e.g. Urinary tract infection, gastritis, Gastroesophagel reflux disease and acid peptic disease were excluded. Then selected patients were placed randomly into two groups i.e. Group A (ondansetron) & Group B (metoclopramide), by using lottery method. Outcome variables like efficacy and tolerability were noted.

Results: Mean age was 29.26±6.26 years. Mean gestational age was 7.92±3.16 weeks. Mean nausea intensity score was 9.03±0.39. Mean number of emesis episodes were 4.53±2.69 / week. Efficacy of Group A (ondansetrone group) was 103 (89.57%) while in Group B (metoclopramide group) efficacy was found in 89 (77.39%) patients with p-value = 0.013.

Conclusion: This study concluded that efficacy and tolerability of ondansetron is better as compared to metoclopramide in hyperemesis gravidarum.

Keywords: Hyperemesis Gravidarum, Antiemetics, Xerostomia.