Background: Considering the importance of maintaining hemodynamic stability in the patient undergoing brain tumor surgery, this study aimed to compare the effects of fentanyl and dexmedetomidine on hemodynamic changes in patients undergoing brain tumor surgery.

Methods: In a clinical trial study, 70 patients undergoing brain surgery were distributed in two groups of 35. The first group received 5 mg / kg fentanyl, and the second group received 1 mg / kg dexmedetomidine immediately after induction of anesthesia. During the operation, the patients were evaluated for hemodynamic parameters, blood gas levels and coagulation profile during operation and recovery and compared between the two groups.

Findings: The mean changes of hemodynamic parameters was not differ between the two groups. Among blood gases HCO3had a higher level of in the dexmedotomidine group before, during and after surgery, and its changes during the study period were significant between the two groups (P <0.001). Also, PT level was higher in the dexmedmotidine group before surgery (P = 0.007), but its change was not significantly different during the study period (P = 0.14).

Discussion: Our findings showed that the use of dexmeditomidine with more favorable hemodynamic stability, shorter hemodynamic presentation, and shorter duration of stay of patients undergoing cerebral surgery. Considering the serious side effects of doxedetomidine administration, it seems that the use of Dexmedetomidine is preferred in patients undergoing brain surgery than fentanyl.

Keywords: Brain tumor, Dexmedmotidine, Fentanyl, Hemodynamic