Objective: To determine the frequency of decompensation in patients with hepatocellular carcinoma in Child Pugh Class A undergoing trans arterial Chemoembolization.

Study Design: Descriptive case series

Place &Duration: Study was conducted at gastroenterology department with collaboration of interventional radiologists Gambat Institute of Medical Science's Khairpur for six months during the time period of November 2020 to April 2021.

Methodology: 218 patients of either sex with hepatocellular carcinoma presenting to Gastroenterology Department fulfilling the inclusion criteria were enrolled in the study. TACE involved injection of a chemotherapeutic agent (doxorubicin) mixed with lipoidol into selectively or super selectively catheterized branches of the arteries feeding the tumor followed by injection of gel foam particles to reinforce the effect of the treatment. Data was used to calculate incidence of decompensation in patients with hepatocellular carcinoma in Child Pugh Class A undergoing transarterial Chemoembolization.

Results: The frequency of decompensation in patients with hepatocellular carcinoma in Child Pugh Class A undergoing transarterial Chemoembolization was 9.2%.

Conclusion: We conclude frequency of decompensation in patients with hepatocellular carcinoma in Child Pugh Class A undergoing transarterial Chemoembolization was 9.2%.

Keywords: Hepatocellular carcinoma, decompensation, chemoembolization