Correlation of Waist Circumference with Monocyte Lymphocyte Ratio, Hemoglobin, and Hba1c in Obesity
Okty Prahalnitya, Meita Hendrianingtyas
2036
ABSTRACT
Background: Obesity is a condition of excessive BMI, accompanied by accumulation of abnormal fat, especially visceral fat. Visceral fat accumulation can be known by measuring waist circumference. Chronic inflammation in obesity, especially central obesity can cause insulin resistance. Monocyte lymphocyte ratio (MLR) is one of the inflammatory markers that is cheap and easy to examine. Anemia can be caused by chronic inflammatory in obesity and interfere by quality of life, activity, and nutrition. HbA1c as one of the glucose parameters can increase because of insulin resistance.
Method: Cross-sectional study of 46 obese young adults, based on WHO criteria during May-September 2018 was done. MLR was measured by manual calculation of differential counts hematology analyzer. Hemoglobin was measured by hematology analyzer and HbA1c was measured by high performance liquid chromatography (HPLC). Pearson test was performed for analyzing data with p <0.05 was significant.
Results: Waist circumference had significant weak positive correlation with MLR and HbA1c respectively (r = 0.376 p = 0.010 ; r = 0.378 p = 0.010) and waist circumference had significant moderate positive correlation with Hb (r = 0.452, p= 0.002).
Conclusions: There was significant weak positive correlation between waist circumference and MLR, and HbA1c. There was significant moderate positive correlation between waist circumference and Hb in obesity. Future examination of inflammatory parameters and anemia is needed for further study
Keywords: Waist circumference, MLR, Hb, and HbA1c.