Introduction: Gynecological diseases affect women’s lives in numerous manners. They are frequent in all communities but the types of disorders and their presentations differ substantially in various regions and races. However, the studies and researches specifying these disorders in particular regions and communities are very low in number.

Hysterectomy is one of the most frequently opted operations worldwide particularly in developing countries and hardly any studies are done about its epidemiology and prevalence in Multan region of Pakistan.

Objective: The objective of this study is to assess the variety of histopathological diseases in patients undergoing hysterectomies in Multan region

Design: Retrospective study including 190 hysterectomy specimens.

Place and duration: Department of Histopathology Bakhtawar Amin Medical & Dental College, Multan from January 2019 to December 2020.

Methodology: Histopathology reports of all hysterectomy specimens removed due to gynecological disorders were included. All the relevant data like age, parity, clinical manifestations, indication and type of hysterectomy were recorded along with histopathological microscopic diagnosis of cervix, endometrium, myometrium, fallopian tubes and ovaries. The data was collected from medical track record, histopathological request form and histopathology report files.

Results: A total of 190 hysterectomies were received in histopathology department. The mean age was 47.8 years (ranging from 25-75 years). Majority of the ladies were between age groups 41-50 years. The major presenting complaint was menstrual irregularity followed by abdominal pain. Out of 190 specimen, 170 (89.5%) of hysterectomies were done because of non neoplastic/ benign conditions. Chronic cervicitis, adenomyosis and leiomyomata were the most commonly noticed incidental findings.

Conclusion: Hysterectomy is an extensively used therapeutic modality, largely for benign non neoplastic disorders to relieve the clinical symptoms and to enhance the living conditions. Presence of incidental diseases in majority of hysterectomy specimens indicates that for conclusive opinion, histopathological examination is must.

Key words: Histopathology, hysterectomy, benign gynecological disorders, leiomyoma, adenomyosis