Association between Lipid Peroxidation and Hypocalcemia in patients with Pregnancy Induced Hypertension (PIH) in a local population of Pakistan
Ghazal Mansoor, Sana Qanber Abbasi, Zahid Bashir, Samra Hafeez, Qurat-Ul-Ain, Zulfiqar Ali, Afsheen Akbar
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ABSTRACT
Background: The study was
carried out to evaluate the effects of calcium on lipid peroxidation in normal
pregnancy and pregnancy induced hypertensive females. It is suggested that
calcium may possibly play a key role in regression of PIH by reducing the
oxidative stress. The study of serum calcium level in PIH advocates the value
of serum calcium as a marker of pregnancy complicated by hypertension. Calcium
supplementation during pregnancy lowers blood pressure and epidemiological data
suggests an inverse correlation between dietary calcium intake and incidence of
PIH.
Methodology: It
was a case control study that included 35 normal pregnant women (NP group), 35
pregnant females with pregnancy induced hypertension (PIH group) and 10 non
pregnant women (control group) between the ages of 18-35 years attending Sharif
Medical City Hospital, Lahore. Venous blood was withdrawn and collected from
the three study groups. It was centrifuged and was used for the estimation of
calcium and malondialdehyde (MDA) the marker of lipid peroxidation.
Results: The results obtained showed that the levels
of MDA were significantly increased in pregnancy induced hypertensive women
(PIH group) when compared with the NP group and control group (P = 0.000). On
the other hand, the level of calcium was significantly reduced in PIH group
when compared with NP group, with an even further decrease in control group (P
= 0.000).
Conclusion: The present evidence supports the concept
that calcium supplements during pregnancy can reduce PIH when given to women
with deficient calcium intake or when they are at risk for PIH.
Keywords: lipid peroxidation, MDA, Calcium, PIH
ABSTRACT
Background: The study was
carried out to evaluate the effects of calcium on lipid peroxidation in normal
pregnancy and pregnancy induced hypertensive females. It is suggested that
calcium may possibly play a key role in regression of PIH by reducing the
oxidative stress. The study of serum calcium level in PIH advocates the value
of serum calcium as a marker of pregnancy complicated by hypertension. Calcium
supplementation during pregnancy lowers blood pressure and epidemiological data
suggests an inverse correlation between dietary calcium intake and incidence of
PIH.
Methodology: It
was a case control study that included 35 normal pregnant women (NP group), 35
pregnant females with pregnancy induced hypertension (PIH group) and 10 non
pregnant women (control group) between the ages of 18-35 years attending Sharif
Medical City Hospital, Lahore. Venous blood was withdrawn and collected from
the three study groups. It was centrifuged and was used for the estimation of
calcium and malondialdehyde (MDA) the marker of lipid peroxidation.
Results: The results obtained showed that the levels
of MDA were significantly increased in pregnancy induced hypertensive women
(PIH group) when compared with the NP group and control group (P = 0.000). On
the other hand, the level of calcium was significantly reduced in PIH group
when compared with NP group, with an even further decrease in control group (P
= 0.000).
Conclusion: The present evidence supports the concept
that calcium supplements during pregnancy can reduce PIH when given to women
with deficient calcium intake or when they are at risk for PIH.
Keywords: lipid peroxidation, MDA, Calcium, PIH