ABSTRACT

Aim: To compare the efficacy of triamcinolone acetonide ointment and bovine basic fibroblast growth factor in the treatment of minor recurrent aphthous ulcer.

Study Design: Comparative study

Place & Duration: Deptt of Medicine, Rehman Medical College Peshawar from 1^st August 2018 to 31^st July 2019.

Methodology: Fifty patients were included in the study. Patients were randomly divided into 2 groups, each containing 25 patients. Group A was treated with 0.1% triamcinolone acetonide oral ointment (5 g/tube, once a day), while group B was treated with recombinant bovine basic fibroblast growth factor (21000IU/5g/tube, three times a day). Patients in the two groups were compared on the basis of visual analog score, time of target ulcer pain relief, target ulcer area index, target ulcer exudation and hyperemia score on 1^st, 3^rd, 5^th and 7^thday of visit.

Results: The healing time of target ulcer in group A and group B was 4.40±1.09 and 6.09±1.50 days respectively, with statistically significant difference (p<0.0001). The onset time of target ulcer analgesia in group A was shorter than that in group B, with statistically significant difference (p<0.001). Visual analog score of group A on day 3 and 7 were significantly improved than group B with p<0.05 each while insignificant differences were found on day 5. On day 3, the target ulcer area index of group A was significantly better than group B (p=0.003). On day 5, the exudation and hyperemia score of group A were improved than group B, with statistically significant difference (p<0.05 each).

Conclusion: Triamcinolone acetonide oral ointment is more effective than basic fibroblast growth factor in the treatment of minor recurrent aphthous ulcer.