ABSTRACT

Objective: To determine the histopathological examination of the esophageal growth endoscopic specimens.

Study design:  Retrospective cross sectional

Study setting and duration: Study was conducted at pathology department of LUMHS, from January 2013 to December 2017.

Material and methods: Patients presented with esophageal dysphagia, underwent endoscopic biopsy, either of gender were selected. All demographic characteristics including endoscopic and Histopathological findings were entered in the proforma for the purpose of analysis by SPSS version 20.

Results: Total 172 patients were enrolled; their mean age was 45.23+8.12 years. Females were in majority 113(65.7%). Most of the patients 86.0% were presented dysphagia, followed by pain, nausea and vomiting. Esophageal growth was commonest finding on endoscopy as 84.3%, followed by stricture 8.7% and inflammation 6.9%. Most of the cases 59.9% histopathologically diagnosed as well differentiated squamous cell carcinoma (SCC), 9.3% moderately differentiated SCC, 2.9% poorly differentiated SCC and adenocarcinoma 5.8%, followed by hyperplasia, dysplasia and barrets esophagus, 8.7%, 5.8% and 1.2% respectively. No significant difference was found in histological findings according to age p-value 0.143. SCC and hyperplasia were significant in male gender p-value 0.001.

Conclusion: It is concluded that SCC commonest histological diagnosis among patients presented with esophageal growth. Endoscopic submucosal dissection has become the gold standard for the resection of superficial specimen for histopathology.