The influence of Breast Cancer Molecular Subtypes on Metastatic pattern in Iraqi patients
Manwarabdulelah Al-Naqqash, Ammarrasoul Mohammed, Zahraa Mohammed Albu-Sultan, Ekhlas Sabah Hassan
863
ABSTRACT
Background: Breast cancer is first of the top
ten malignancies in Iraq.
Aim: To discuss, explore, and describe clinico-pathologic features, and
metastasis patterns of breast cancer according to molecular subtypes.
Methods: A retrospective study of 315 metastatic breast cancer women
was performed. The study conducted at Baghdad Medical City, in a period for 6
months between January 2019 and June 2019. The HR expression status, and HER2
gene amplification were evaluated by IHC. The associations of molecular
subtypes, and distant metastases modeled by regression analysis and correlation
tests. Furthermore, the Box-Ljung test, the Bartlett's scale, and Kaplan-Meier
survival curveused.
Results: Age was most
frequent in group 46-55 years, as 107(34%) patients. The BMI characterized by moderate obesity as 89(28.3%). The IDC
was the most common histopathology 273(87%) patients. The T2 stage rank first
with 168(58.5%), with high frequency of N1 staging in 93(32.5%). Bone was the
common metastatic site. The HR positive, and Her 2neu negative recorded
doubling than opposite. The HR+/HER- was the prominent subtypes as 141(57.1%).
All subtypes were significantly associated with all sites of metastasis that
analyzed by univariate, and multivariate.
Conclusions: The BMI has high
impaction as a risk factor for breast cancer. The HR+/HER- have better
prognosis & best survival. The metastasis presentations are strongly
associated with molecular subtype patterns.
Keywords: Breast cancer; HR+/HER-; Her 2neu; Molecular
subtypes
ABSTRACT
Background: Breast cancer is first of the top
ten malignancies in Iraq.
Aim: To discuss, explore, and describe clinico-pathologic features, and
metastasis patterns of breast cancer according to molecular subtypes.
Methods: A retrospective study of 315 metastatic breast cancer women
was performed. The study conducted at Baghdad Medical City, in a period for 6
months between January 2019 and June 2019. The HR expression status, and HER2
gene amplification were evaluated by IHC. The associations of molecular
subtypes, and distant metastases modeled by regression analysis and correlation
tests. Furthermore, the Box-Ljung test, the Bartlett's scale, and Kaplan-Meier
survival curveused.
Results: Age was most
frequent in group 46-55 years, as 107(34%) patients. The BMI characterized by moderate obesity as 89(28.3%). The IDC
was the most common histopathology 273(87%) patients. The T2 stage rank first
with 168(58.5%), with high frequency of N1 staging in 93(32.5%). Bone was the
common metastatic site. The HR positive, and Her 2neu negative recorded
doubling than opposite. The HR+/HER- was the prominent subtypes as 141(57.1%).
All subtypes were significantly associated with all sites of metastasis that
analyzed by univariate, and multivariate.
Conclusions: The BMI has high
impaction as a risk factor for breast cancer. The HR+/HER- have better
prognosis & best survival. The metastasis presentations are strongly
associated with molecular subtype patterns.