Diagnostic Accuracy of Qualitative Diffusion Weighted MRI of Spine
UsmanZafar, AdeelAsghar Malik, IrumShahzad, MutahiraMannan, QuratUlAinSahi, Sameera Amir
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ABSTRACT
Background: Qualitative diffusion weighted magnetic
resonance imaging of spine can be used to determine the nature of lesion.
Current study was carried out to find the diagnostic accuracy.
Aim: To determine the diagnostic accuracy of
qualitative diffusion weighted magnetic resonance imaging of spine in
differentiating between benign and malignant vertebral fractures.
Study duration:1st July 2016 to 30th
June 2017.
Methods: 280 patients with vertebral fractures on digital x
ray of spine showing decreased vertebral body height, reduced disc
intervertebral disc space or collapsed vertebra as reported by a radiologist
were included. Magnetic resonance imaging of spine both plain and diffusion
weighted Imaging was carried out. A single consultant radiologist reported the
Vertebral Fracture as benign or malignant lesion without prior knowledge of
biopsy results.
Results: Mean
age was 42.61 ± 11.79. 156 patients (55.7%) were male and rest of 124 patients
(44.3%) were female. 25 patients (8.9%) showed up with malignant lesion on MRI
whereas 255 patients (91.1%) had benign lesion. 32 patients (11.4%) showed up
with malignant lesion on histopathology whereas 248 patients (88.6%) had benign
lesion. For whole cohort, we came up with sensitivity53.12%, specificity
96.77%, positive predictive value 68%, negative predictive value 94.11% and
diagnostic accuracy 91.78%.
Conclusion: This study concluded that diagnostic accuracy of
qualitative diffusion weighted magnetic resonance imaging of spine in
differentiating malignant and benign vertebral fractures is acceptable at
current sample size.
Keywords: Magnetic resonance imaging, vertebral fractures,
sensitivity.
ABSTRACT
Background: Qualitative diffusion weighted magnetic
resonance imaging of spine can be used to determine the nature of lesion.
Current study was carried out to find the diagnostic accuracy.
Aim: To determine the diagnostic accuracy of
qualitative diffusion weighted magnetic resonance imaging of spine in
differentiating between benign and malignant vertebral fractures.
Study duration:1st July 2016 to 30th
June 2017.
Methods: 280 patients with vertebral fractures on digital x
ray of spine showing decreased vertebral body height, reduced disc
intervertebral disc space or collapsed vertebra as reported by a radiologist
were included. Magnetic resonance imaging of spine both plain and diffusion
weighted Imaging was carried out. A single consultant radiologist reported the
Vertebral Fracture as benign or malignant lesion without prior knowledge of
biopsy results.
Results: Mean
age was 42.61 ± 11.79. 156 patients (55.7%) were male and rest of 124 patients
(44.3%) were female. 25 patients (8.9%) showed up with malignant lesion on MRI
whereas 255 patients (91.1%) had benign lesion. 32 patients (11.4%) showed up
with malignant lesion on histopathology whereas 248 patients (88.6%) had benign
lesion. For whole cohort, we came up with sensitivity53.12%, specificity
96.77%, positive predictive value 68%, negative predictive value 94.11% and
diagnostic accuracy 91.78%.
Conclusion: This study concluded that diagnostic accuracy of
qualitative diffusion weighted magnetic resonance imaging of spine in
differentiating malignant and benign vertebral fractures is acceptable at
current sample size.
Keywords: Magnetic resonance imaging, vertebral fractures,
sensitivity.