ABSTRACT

Background: Benign Prostate Hyperplasia is the most common benign neoplasm in older men.According to the high prevalence of Benign Prostate Hyperplasia in older Iranian men, it seems that vitamin Ddeficiencycan play an important role in the development of BPH.

Materials and Methods: This study was performed as a case control atKamkarArabnia Educational and Medical Hospital, Qom in 2018. In this study, participants were divided into 2 groups of people with BPH and the control group (healthy people). All these people were tested for vitamin D by HPLC and their results were analyzed.

Results: The average age of the patients with BPH and in the control group was 67and 57 years, respectively. Most of the participants had free jobs (n= 77, 47.8%). 101 out of the 161 (62.7%) were underdiploma. 153 out of the 161 (95%) were urban. 89 out of the 161 (55.3%) had no underlying disease and 72 out of the 161 (44.7%) had underlying disease. 89 out of the 161 (55.3%) were smokers. Eighty patients (49.7% of total participants) had BPH. Although there was no significant relationship between smoking and BPH in the participants, however there was a significant association between serum levels of vitamin D and BPH in the subjects (P = 0.001). Most people with BPH had a freelance job, but no statistically significant association was found between job status and BPH (P = 0.92). In addition, there was no significant relationship between BPH and education level of individuals (P= 0.412).

Conclusion: According to the results of the present study, it can be concluded that there is a significant association between vitamin D level and prostate volume. Therefore, it is recommendedthat patients with BPH be tested for vitamin D levels and if needed vitamin D supplements be prescribed.