Objective: Aim of this study is to determine the Covid-19 can be a leading cause of death in patients who had acute liver disease cirrhosis.

Study Design: Comparative/retrospective study

Place and Duration: King Salman Armed Forces Hospital Tabuk, Saudia Arabia/ Rashid Latif Medical College, Lahore. December 2020-May 2021

Methodology: People with or without chronic liver illness were involved in this research, which comprised 130 covid-19 individuals of both genders. It became out that there were two different groups of patients. Group A (which included 65 patients with cirrhosis) and Group B (which included 65 individuals without cirrhosis). Comorbidities among both groups were also assessed. Comparing the death rates of the two groups was done. For all of the data analysis, the SPSS 23.0 was employed. 

Results: The mean age of the patients in group I was 40.01±1.35 years and in group II mean age were 39.11±6.32 years. Males were the most common patients among both groups 42 (64.6%) in group A and 45 (69.2%) in group B. Alcohol abuse and viral hepatitis were the most common causes among all cases. Diabetes mellitus, hypertension and pulmonary disease were the most common comorbidities. Significantly higher hospital stay was fund in group A 40.1±7.42 days as compared to group B 17.12±2.47 days with p value <0.005. We found mortality rate in cirrhosis group was higher 24 (36.9%) as compared to non-cirrhotic group 8 (12.3%).

Conclusion: We concluded that patients of Covid-19 with liver disease had higher rate of mortality with excess number of comorbidities as compared to the non-cirrhotic Covid-19 patients.