Association of AVPR1A Polymorphism with Criminal Intent
Anam Iqbal, Usman Shahid Butt, Nasreen Akhtar, Riasat Ali, Tooba Ali, Sadia Zaheer
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ABSTRACT
Background: The human
behavior is influenced by genetic as well as environment components. Likewise,
the aggressive behavior having an intent of criminality is also governed by
both environmental and genetic makeup.
Aim: The genetic element has been explored by
analyzing the microsatellite RS1 and RS3 of AVPRIA gene which showed strong
variations in short tandem repeats (STRs) of convicted offenders when they were
compared with normal population.
Methods: Blood samples of 100 convicted
offenders were taken and DNA was extracted using PCI protocol. The PCR was then
carried out using primers and the products were send for gene sequencing. The
results were compared with that of general population having no history of
crime or psychological abnormality.
Results: The microsatellite RS1 and RS3 of
AVPRIA gene showed strong variations in short tandem repeats (STRs) of
convicted offenders when they were compared with normal population.
Keywords: AVPR1A, criminal intent, PCR