Objective: To assess the prevalence of hepatitis B and C among elderly patients at different clinical settings of three major cities of Sindh, Pakistan. Study Design: Cross sectional observational study Place and Duration of Study: Department of Department of Medicine, Muhammad Medical College, Mirpurkhas from 1st November 2020 to 30th June 2021. Methodology: One thousand and two hundred patients from three different cities of Sindh Province either gender, ages and type of hepatitis were recorded.

Results: There were 60.83% males and 39.17% females. 35.83% patients belonged to age >50 years while the prevalence rate of hepatitis was 9.16, hepatitis C 10.33 and both was 4.83%. The patients of hepatitis C was found in females than males. Hepatitis B and C was also more prevalent in more than 50 years of age. Conclusion: The prevalence rate of Hepatitis B, C and both, however the male gender is at more risk of hepatitis possibility due to expended social life circle and other contributing risk factors such as blood transfusion, frequent physical contacts and exposure to contaminated instruments at salons. Key words: Prevalence, Hepatitis B & C, Gender