ABSTRACT

Peptide and protein drug are commercially available as therapeutics and are prepared by various biotechnology processes.As they lack drug stability during their delivery, so protein structures are modified to maintain pharmaceutical properties of proteins. Various approaches for delivery of protein and peptide drugs are used for proper formulation of drugs. In addition, various advancements in protein and peptide drug delivery have try to overcome the issues during delivery of these therapeutics like increased stability, low toxicity level and increased resistance to proteolytic inactivation, bioavailability, efficiency and improve circulation period. There is a need to develop multifunctional drugdelivery systems and advance technologies that allow production of high quality products at affordable cost. The study was conducted to check various approaches and recent advances in protein/peptide drug delivery system to improve patient compliance when compared with conventionalmethods for drug delivery.

Keywords: Protein and peptide, drug delivery system, microspheres, liposomes, nanoparticles, PE Gylation