ABSTRACT

Aim:To find out frequency of hyponatremia in cases of Hepatic Encephalopathy.

Methods:This cross sectional study was conducted at Department of Pathology, Quaid-e-Azam Medical College Bahawalpur from March 2020 to September 2020.Total 190 patients of HE from Department of Medicine Bahawal Victoria Hospital, Bahawalpur were selected and hyponatremia was analyzed in selected patients. Results: Mean age of the patients was 39.43 ± 12.90 mean duration of HE was 8.21 ± 5.50 hours.Out of 190 patients, hyponatremia was found in 63 (33%) patients.Total 105 (55.26%) patients belonged to age group 20-40 years and 85(44.74%) patients belonged to age group 41-60 years. Hyponatremia was noted in 38(36.19%) patients of age group 20-40 years and in 25(29.41%) patients of age group 41-60 years. 1-12 hours group was consisted on 150 (78.95%) patients while 13-24 hours group was consisted on 40(21.05%) patients. Hyponatremia was found in 43(28.67%) patients of 1-12 hours group and in 20(50%) patients of 13-24 hours group.Statistically significant association between hyponatremia and duration of HE was noted with p value 0.011.

Conclusion: Findings of presents study showed a higher rate of hyponatremia in cases of HE.Most of the cases were between 20-40 years.A higher number of male patients found suffering from HE as compared to female patients.Most of the patients reported within 12 hours of onset of HE and hyponatremia was significantly associated with duration of HE. Keywords: Hepatic encephalopathy, hyponatremia, liver cirrhosis, ischemic stroke.