ABSTRACT

Aim: To compare frequency of haemodynamic stability of Nalbuphine-Propofol and Pethidine-Propofol combination at induction of general anesthesia to patients undergoing elective surgeries.

Methodology: It was a randomized controlled trial study. Age 20–50 years from both genders. ASA I & II: Patients falling in ASA category I & II. Patients for elective abdominal surgeries under general anaesthesia. Out of 200 patients, 100 patients were enrolled in each group of combination i.e. Propofol-Pethidine and Propofol-Nalbuphine.

Place and duration of study: This study was conducted in the Department of Anaesthesiology and Intensive Care Unit at Shaikh Zayed Hospital, Lahore from 01-12-2011 to 31-05-2012

Results: Age, weight, gender and ASA status were found to be insignificant. The trend of heart rate increased in Pethidine group and decreased in Nalbuphine group within three minutes with significant p <0.001. Systolic blood pressure decreased in both groups within the study time with significant p <0.001. 82% of patients from Pethidine group while 74% in Nalbuphine group had heart rate within 20% of the baseline (p <0.001) at 1 minute. At 2 minutes 67% and 49% patients in Pethidine and Nalbuphine group respectively, fell within 20% of the baseline (p <0.001). Similarly at 3 minutes 72% and 43% of patients in both groups respectively had stable heart rate (p <0.001). While monitoring systolic blood pressure, 74% in Pethidine group and 34% in Nalbuphine group fell within 20% of the baseline at 1 minute. At 2 minutes it reduced to 27% and 12% respectively in both groups (p 0.012). Conclusion: It is concluded that either combination Pethidine-Propofol or Nalbuphine-Propofol can be used as induction agent but Pethidine-Propofol is a better choice and provides better haemodynamic stability and better analgesia, recovery profile and postoperative pain relief.

Keywords: Hemodynamic stability, Nalbuphine-Propofol, Pethidine-Propofol, Heart rate and Systolic BP.