Advances in Colonoscopy for Colorectal Cancer Screening: A Comparison between Chromocolonoscopy Vs Colonoscopy
Zaeem Sibtain, Salman Taj Uppal, Muhammad Affan Qaiser, Muhammad Kamran Yousaf, Syed Hammad W. Talha Shah, Nazish Butt
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ABSTRACT
Aim: A comparison between chromocolonoscopy versus white light colonoscopy in
screening colorectal cancer
Methods: Patients were randomly
assigned to high-definition white light colonoscopy (HDWLC) and high-definition
chromocolonoscopy (HDCH). The patients were divided into two groups, each had
110 individuals
Results: An adenoma affected 1.2 to
2.1 patients on average, while polyps affected 1.4 to 1.9 patients on average,
with an adenoma affecting 0.5 to 1.0 patient on average. Both the number of
patients with at least one adenoma (54.5% vs. 47.2%, absolute difference 7.3%,
95% confidence interval (p value <0.01) and the number of adenomas per patient
(1.2 versus 1.0, P <0.01) were slightly higher in the chromocolonoscopy
group. Adenomas that had progressed by 10 mm or more differed from those that
had progressed by <10 mm (0.16 versus 0.14, P = 0.4), although the
differences were not statistically significant. In each group, one invasive
malignancy was discovered, and it wasn't a benign tumor or neoplasm. By
chromocolonoscopy, non-neoplastic lesions (1.9 per patient versus 1.1 per
patient, P = 0.01) were detected significantly more frequently than adenomas
larger than 5 mm in diameter (0.9 per patient versus 0.8 per patient, P <
0.01)
Conclusion: When compared to
high-definition white light colonoscopy, high-definition chromocolonoscopy had
a marginally greater rate of adenoma diagnosis and a moderate increase in flat
adenomas and small lesions but not in large lesions. When it came to more
advanced malignancies, both techniques produced the same results.
Keywords: Colorectal cancer, chromocolonoscopy
ABSTRACT
Aim: A comparison between chromocolonoscopy versus white light colonoscopy in
screening colorectal cancer
Methods: Patients were randomly
assigned to high-definition white light colonoscopy (HDWLC) and high-definition
chromocolonoscopy (HDCH). The patients were divided into two groups, each had
110 individuals
Results: An adenoma affected 1.2 to
2.1 patients on average, while polyps affected 1.4 to 1.9 patients on average,
with an adenoma affecting 0.5 to 1.0 patient on average. Both the number of
patients with at least one adenoma (54.5% vs. 47.2%, absolute difference 7.3%,
95% confidence interval (p value <0.01) and the number of adenomas per patient
(1.2 versus 1.0, P <0.01) were slightly higher in the chromocolonoscopy
group. Adenomas that had progressed by 10 mm or more differed from those that
had progressed by <10 mm (0.16 versus 0.14, P = 0.4), although the
differences were not statistically significant. In each group, one invasive
malignancy was discovered, and it wasn't a benign tumor or neoplasm. By
chromocolonoscopy, non-neoplastic lesions (1.9 per patient versus 1.1 per
patient, P = 0.01) were detected significantly more frequently than adenomas
larger than 5 mm in diameter (0.9 per patient versus 0.8 per patient, P <
0.01)
Conclusion: When compared to
high-definition white light colonoscopy, high-definition chromocolonoscopy had
a marginally greater rate of adenoma diagnosis and a moderate increase in flat
adenomas and small lesions but not in large lesions. When it came to more
advanced malignancies, both techniques produced the same results.
Keywords: Colorectal cancer, chromocolonoscopy