Sadia Sundus, Maria Khan, Sarwat Fatmee, Muhammad Imran, Safia Naz, Madiah Ajaz

Impact of Celecoxib on Serum Creatinine along with Beneficial Effects of Lycopene on Albino Rats; an Observational Study

Sadia Sundus, Maria Khan, Sarwat Fatmee, Muhammad Imran, Safia Naz, Madiah Ajaz



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ABSTRACT

Objective: To assess the impact of celebrex on serum creatinine with augmentation by lycopene.

Study design: observational study.

Place of study: Animal House, JPMC, Karachi,

Period of study: 4th May 2015 to 3rd June 2015. 

Materials and Methods: Forty fully-grown male Albino rats of 200-220gm weight and 3-4 months old were reserved for this study and separated into 4 groups, control was selected as A1, In A2 50 mg/kg Celebrex was given by oral route, In A3 50 mg/kg Celebrex was given by oral route along with lycopene and In A4 50mg/kg lycopene was given by oral route. At completion of experimental study, all animals were dissected and preserved.

Results: In A2 animals serum creatinine level was significantly elevated, however level was improved in A3 animal group.

Conclusion: Experiment discloses that lycopene improve the raised serum levels of A2.

Keywords: Celebrex, GI adversity, cyclooxygenase, PG.



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