Correlation of COVID-19 Genome with Hypoxemia and Co-morbidities: Experimental Study
Saveela Sadaqat, A. Ashar Ghuman, Saifullah, Mahak Memon, Muhammad Akram, Ali Faheem, M. Zeeshan Anwar, Zaeem-ul-Saqib, Talha Laique
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ABSTRACT
Background: The Covid-19
pandemic has wreaked havoc throughout the world, with 150 million cases to date
and over 3 million lives claimed worldwide.
Aim: To explore the hypoxemia in COVID-19 patients in relation
with genomic mutation and co-morbidities.
Study
Design: Experimental Study.
Methodology: A total of 16 COVID-19 positive patients
admitted to Aziz Bhatti hospital were included in this study. COVID-19 was
confirm through nasopharyngeal swab specimen diluted in normal saline
subsequent RT-PCR was performed as per the standard operating procedure. Genome
sequencing and interpretation of analysis was done through Illumina MiSeq.
Results: There was statistically
significant difference (P < 0.05) in SaO2 in patients with N (Nucleocapisd)
protein mutation compared with NSP13( Helicase) mutation.
Conclusion: It was concluded that mutation of N
(Nucleocapisd) protein causes more pronounced hypoxia compared with Helicase mutation of COVID-19
genome.
Keywords: COVID-19, Hypoxia, Mutation and Genome.
ABSTRACT
Background: The Covid-19
pandemic has wreaked havoc throughout the world, with 150 million cases to date
and over 3 million lives claimed worldwide.
Aim: To explore the hypoxemia in COVID-19 patients in relation
with genomic mutation and co-morbidities.
Study
Design: Experimental Study.
Methodology: A total of 16 COVID-19 positive patients
admitted to Aziz Bhatti hospital were included in this study. COVID-19 was
confirm through nasopharyngeal swab specimen diluted in normal saline
subsequent RT-PCR was performed as per the standard operating procedure. Genome
sequencing and interpretation of analysis was done through Illumina MiSeq.
Results: There was statistically
significant difference (P < 0.05) in SaO2 in patients with N (Nucleocapisd)
protein mutation compared with NSP13( Helicase) mutation.
Conclusion: It was concluded that mutation of N
(Nucleocapisd) protein causes more pronounced hypoxia compared with Helicase mutation of COVID-19
genome.
Keywords: COVID-19, Hypoxia, Mutation and Genome.