Evaluation of Different Diagnostic Modalities in Breast Cancer - A Systematic Review
Javairia Rafique, Syed Amir Gilani, Syeda Khadija-Tul-Sughra Murrium, Tauseef Ahmad, Aima Gilani, Waleed Jameel
16
ABSTRACT
Background: Most common cancer in women that is 32 % of all newly diagnosed cancers
is breast cancer. Breast cancer develops when cells of your breast multiply and
divide uncontrollably, resulting in a lump of tissue known as a tumor.
Screening type of mammography has played a key role in reducing breast cancer
mortality.
Aim: To evaluate role
of three diagnostic modalities in the breast cancer.
Methods: The
data bases PubMed and other search engines were searched with the key words:
breast cancer, mammography, ultrasound, MRI, sensitivity, specificity, from
1999 to 2020. For inclusion and exclusion of studies we screened the most
relevant and irrelevant outcomes. Studies having information of breast cancer,
mammography, ultrasound, MRI, sensitivity, specificity was included.
Meta-analysis were excluded.
Results: In total 39 studies with breast cancer the overall mean
sensitivity of ultrasound, mammography and MRI were 76.81, 74 and 88.18
respectively. Overall mean specificity of ultrasound, mammography and MRI
79.65, 87 and 75.17 respectively. SD of Sensitivity and Specificity of MRI is
10.57 and 16.27. SD of Sensitivity and Specificity of mammography is 20.92 and
16.43. SD of Sensitivity and Specificity of ultrasound is 23.71 and 20.05.
Conclusions:
MRI, because of its limitations cannot be used routinely for diagnosing breast
cancer. Mammography is readily available screening tool for breast cancer
however it has low sensitivity for diagnosis of breast cancer and requires
complimentary imaging. Ultrasound can be used as baseline modality as it saves
time and safe in all conditions.
Keywords: Breast Cancer,
Mammography, Ultrasound, MRI, Sensitivity, Specificity
ABSTRACT
Background: Most common cancer in women that is 32 % of all newly diagnosed cancers
is breast cancer. Breast cancer develops when cells of your breast multiply and
divide uncontrollably, resulting in a lump of tissue known as a tumor.
Screening type of mammography has played a key role in reducing breast cancer
mortality.
Aim: To evaluate role
of three diagnostic modalities in the breast cancer.
Methods: The
data bases PubMed and other search engines were searched with the key words:
breast cancer, mammography, ultrasound, MRI, sensitivity, specificity, from
1999 to 2020. For inclusion and exclusion of studies we screened the most
relevant and irrelevant outcomes. Studies having information of breast cancer,
mammography, ultrasound, MRI, sensitivity, specificity was included.
Meta-analysis were excluded.
Results: In total 39 studies with breast cancer the overall mean
sensitivity of ultrasound, mammography and MRI were 76.81, 74 and 88.18
respectively. Overall mean specificity of ultrasound, mammography and MRI
79.65, 87 and 75.17 respectively. SD of Sensitivity and Specificity of MRI is
10.57 and 16.27. SD of Sensitivity and Specificity of mammography is 20.92 and
16.43. SD of Sensitivity and Specificity of ultrasound is 23.71 and 20.05.
Conclusions:
MRI, because of its limitations cannot be used routinely for diagnosing breast
cancer. Mammography is readily available screening tool for breast cancer
however it has low sensitivity for diagnosis of breast cancer and requires
complimentary imaging. Ultrasound can be used as baseline modality as it saves
time and safe in all conditions.
Keywords: Breast Cancer,
Mammography, Ultrasound, MRI, Sensitivity, Specificity