Clinical and Immunological Profile of Childhood Systemic Lupus Erythematosus: Observational Study
Sobia Qamar, Samia Naz, Saima Batool, Rabeya Rehman, Asma Mushtaq, Muhammad Yasin Alvi, Talha Laique
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ABSTRACT
Background: Childhood SLE is a severe autoimmune disease involving multiple systems
that effect peoples globally.
Aim: To
delineate the spectrum of clinical manifestations of childhood SLE at the Government
Children’s Hospital Lahore.
Study design: Descriptive observational study.
Methodology:
Study was carried out at department of
Pediatric medicine, unit 1, Children’s hospital Lahore from January 2016 to
December 2019. Applying a nonprobability convenience sampling technique,
children between 1-16 years of age with childhood systemic lupus erythematosus
attending rheumatology outpatient clinic or admitted through emergency were
included in study. Written and verbal informed consent was obtained after
explanation of study purpose.
Results: There were 59 (78.70%) female and 16 (28.3%)
male patients enrolled in the study. Mean age at diagnosis was 10.89±3.4%
years. Female predominance was noticeable. Amongst the
clinical features fever (96%) was the commonest, followed by oral ulcers
(74.70%), alopecia (72%), renal manifestations (69.30%), rash (61.30%),
arthritis (56%), and hematological abnormalities (48%), photosensitivity (44%),
neurological features (36%) in 24% of patients.
Conclusion: It was concluded that disease was
prevalent among all races around the world but in South Asia there are few
studies available on its prevalence. Timely diagnosis by a detailed history,
physical examination and laboratory evaluation can improve the chances of
prolonged disease-free periods and better survival of children.
Keywords: Childhood SLE, ACR and SLICC.
ABSTRACT
Background: Childhood SLE is a severe autoimmune disease involving multiple systems
that effect peoples globally.
Aim: To
delineate the spectrum of clinical manifestations of childhood SLE at the Government
Children’s Hospital Lahore.
Study design: Descriptive observational study.
Methodology:
Study was carried out at department of
Pediatric medicine, unit 1, Children’s hospital Lahore from January 2016 to
December 2019. Applying a nonprobability convenience sampling technique,
children between 1-16 years of age with childhood systemic lupus erythematosus
attending rheumatology outpatient clinic or admitted through emergency were
included in study. Written and verbal informed consent was obtained after
explanation of study purpose.
Results: There were 59 (78.70%) female and 16 (28.3%)
male patients enrolled in the study. Mean age at diagnosis was 10.89±3.4%
years. Female predominance was noticeable. Amongst the
clinical features fever (96%) was the commonest, followed by oral ulcers
(74.70%), alopecia (72%), renal manifestations (69.30%), rash (61.30%),
arthritis (56%), and hematological abnormalities (48%), photosensitivity (44%),
neurological features (36%) in 24% of patients.
Conclusion: It was concluded that disease was
prevalent among all races around the world but in South Asia there are few
studies available on its prevalence. Timely diagnosis by a detailed history,
physical examination and laboratory evaluation can improve the chances of
prolonged disease-free periods and better survival of children.
Keywords: Childhood SLE, ACR and SLICC.