Effect of Intravitreal Triamcinolone (IVT) Injection on Visual Acuity in Patients with Ischemic CRVO
Salahuddin, Zubairullah Khan, Muhammad Ayub Khan, Afrasiab, Abdul Aziz, Mariam Zakia Chaudhari
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ABSTRACT
Aim: To govern the
intravitreal injection effect of triamcinolone (IVT) on visual acuity in
patients with ischemic central retinal vein obstruction (CRVO).
Study Design: A randomized clinical
trial.
Methods:The patients with
ischemic event of CRVO less than amonth who were referred to the ophthalmology
departmentof Hayatabad Medical Complex,
Peshawar and Woman Medical and Dental College, Abbottabad. Patents were
included for the duration from March
2021 to August 2021.Inclusion criteria were: < one month duration of
CRVO, normal intraocular pressure, no symptoms of hypertensive or diabetic retinopathy,
history of eye surgery or laser therapy, and no vascular disease. Patients were
randomized into 2 groups: control group (no injection) and intervention group
(0.1 cc IVT injection). Follow-up is scheduled for 1, 2, 3 and 6 months after
injection for all patients. The main outcomes of the study were evaluated and
used for statistical analysis were SPSS software version 21.0 ion test-t
statistical test.
Results:70 patients (36 men
and 34 women) participated in the study. 62.1 ± 8.9 was the mean age of
patients (range: 30-80). The time of symptoms was 20 ± 4.9 days in the control
group and in the IVT group; duration was 19 ± 6 days (p = 0.65). All subjects
had symptoms of ischemic CRVO. The IVT group has mean baseline visual acuity of
1.80 ± 0.19 logMAR and in the control group; it was 1.91 ± 0.08 logMAR (p =
0.1). The enhancement in VA in the IVT group was better after one month as
compared to the control group (p = 0.018); though, this variance was not
significant in other control studies. Also, before and after injection; the alteration
in IOP was not significant (p = 0.802).
Conclusions: This analysisexhibited
that triamcinolone intravitreal injection had no substantial long-term outcome
on visual acuity among CRVO patients.
Keywords:Triamcinolone, Central
Retinal Vein Occlusion
ABSTRACT
Aim: To govern the
intravitreal injection effect of triamcinolone (IVT) on visual acuity in
patients with ischemic central retinal vein obstruction (CRVO).
Study Design: A randomized clinical
trial.
Methods:The patients with
ischemic event of CRVO less than amonth who were referred to the ophthalmology
departmentof Hayatabad Medical Complex,
Peshawar and Woman Medical and Dental College, Abbottabad. Patents were
included for the duration from March
2021 to August 2021.Inclusion criteria were: < one month duration of
CRVO, normal intraocular pressure, no symptoms of hypertensive or diabetic retinopathy,
history of eye surgery or laser therapy, and no vascular disease. Patients were
randomized into 2 groups: control group (no injection) and intervention group
(0.1 cc IVT injection). Follow-up is scheduled for 1, 2, 3 and 6 months after
injection for all patients. The main outcomes of the study were evaluated and
used for statistical analysis were SPSS software version 21.0 ion test-t
statistical test.
Results:70 patients (36 men
and 34 women) participated in the study. 62.1 ± 8.9 was the mean age of
patients (range: 30-80). The time of symptoms was 20 ± 4.9 days in the control
group and in the IVT group; duration was 19 ± 6 days (p = 0.65). All subjects
had symptoms of ischemic CRVO. The IVT group has mean baseline visual acuity of
1.80 ± 0.19 logMAR and in the control group; it was 1.91 ± 0.08 logMAR (p =
0.1). The enhancement in VA in the IVT group was better after one month as
compared to the control group (p = 0.018); though, this variance was not
significant in other control studies. Also, before and after injection; the alteration
in IOP was not significant (p = 0.802).
Conclusions: This analysisexhibited
that triamcinolone intravitreal injection had no substantial long-term outcome
on visual acuity among CRVO patients.
Keywords:Triamcinolone, Central
Retinal Vein Occlusion