ABSTRACT

Introduction: Laryngeal carcinoma is a malignant squamous metaplasia of the overlying epithelial surface of larynx. Several factors are believed to affect the survival of laryngeal carcinoma. This study aims to identify the survival of patients with laryngeal carcinoma.

Materials and Methods: This was a retrospective cohort study using Cox Regression analysis for the survival analysis design. Patients were included if they were diagnosed with laryngeal cancer, had radiotherapy, chemotherapy, surgery or combination therapy and had a complete medical record. Data were collected retrospectively from medical records, such as smoking, alcohol consumption, genetic, tumor location, stadium, and therapy.

Result: The results shows that from the 149 patients with laryngeal carcinoma who came to Head and Neck Surgery oncology outpatient clinic and had received therapy in the period January 2009 to December 2014, it was founded that smoking, alcohol, genetic, staging, surgery, and chemotherapy had a significant relationship to the laryngeal carcinoma survival (p value <0.05). While the location of the tumor and radiation did not show a significant relationship (p value> 0.05). Based on multivariable analysis of Cox Regression obtained smoking, alcohol, and surgery which provides a significant influence on survival. Patients who smoke have a risk of death 23.9 times. Suffering from consuming alcohol has a risk 2.41 times of death. Patients who do surgery can reduce the risk of death about 54%.  Conclusion: The 5-year survival of patients with laryngeal carcinoma is 56.4%.

Keywords: Patient Factors, Prognostic Factors, Tumor Factors, Laryngeal Carcinoma, Survival