Effect of Aqueous Extract of Garlic and Licorice on Carbon Tetra Chloride induced Liver Fibrosis by evaluating serum Aspartate Amino Transferase (AST) and Serum Alanine Amino Transferase (ALT)
Asia Firdaus, Shazia Asim, Ammarah Hasnain,Shahid Hamid, Sana Tufail, Hammad Hussain
1949
ABSTRACT
Background: Hepatic fibrosis results from various chronic insults such as chronic hepatitis B and C, parasitic
disease, autoimmune hepatitis, nonalcoholic steatohepatitis (NASH) and hereditary metal over load e.g. iron and
cupper and it is linked with remarkable morbidity and mortality
Aim:T o evaluate and compare the antifibrotic effect of Aqueous Garlic extract and Licorice Aqueous extract on
carbon tetrachloride induced hepatic fibrosis in rats.
Method:4 groups of rats were taken. In group A and group B, rats were given injection of normal saline
intraperitonally. In group C and D, rats were given injection of Aqueous garlic extract (AGE) and licorice aqueous
extract (LAE) 01 ml / Kg body weight of rat /day intraperitonally for next four weeks respectively. At the end, all rats
were sacrificed. Blood and liver were taken for biochemical examination.
Results: This study results showed that the use of aqueous garlic extract and aqueous licorice extract reduces
CCl4 induced liver fibrosis in rats.
Keywords: Aqueous garlic extract (AGE), licorice aqueous extract (LAE), hepatic fibrosis, anti-fibrotic effect