Background: Valproic acid (VA) serve as the antimigraine, anti-mental disturbances agent and antiepileptic medicine. After using VA, metabolic rearrangements seen in patients that include alteration in lipoproteins levels; however, this topic is still under discussion and disputable.

Aim: To discuss the effects of VA after using for long duration on total levels of cholesterol in adult.

Methods: About Eighty candidates participated and they were divided into two groups namely, case group (40 candidates) and control groups40 candidates). All the candidates were asked for collection of venous blood sample in order to determine total cholesterol serum level among them via aid of enzymatic cholesterol oxidase phenol 4-aminoantipyrine peroxidase. By the aid of the logistic regression analysis, the relationship of the long-term VA treatment and the level of total cholesterol was obtained. With respect to our analysis, there is a co relation between total levels of cholesterol and long term usage of VA (P=0.003). Results: There were no noteworthy link for age, sex, body BMI, height medication usage, smoking, diabetes mellitus and VA dosage , except combination of anti-epileptic drugs

Conclusion: In a net shell, by using VA for long duration, the total level of cholesterol in adults reduces.

Keywords: Lipid profile, side effects, total cholesterol, valproic acid