Background: The educational efficacy in resuscitation could be improved by enhancing instructional design through different innovative approaches especially in resource-limited settings.

Aim: To determine the educational efficacy of diverse strategies on knowledge and skill of nursing students regarding neonatal resuscitation.

Study design: Quasi-experimental study.

Place and duration of study: School of Nursing, Allama Iqbal Medical College, Lahore from 1st November 2020 to 30th April 2021.

Methodology: Sixty-five nursing students of 1st and 2nd professionals were selected. The education on neonatal resuscitation consists of diverse educational strategies including didactic lecture, video, simulation, and self-practice sessions in the simulation laboratory of a public school of nursing in Lahore, Pakistan. The data on knowledge and skill was assessed two times before and after the intervention.

Results: The study showed a significant (p<0.001) change in knowledge and skill after education. Nearly, all students had poor knowledge and skill before education. The knowledge had been improved as 40.0%of students achieved good, and 53.3% achieved fair knowledge level.

Conclusion: The diverse educational strategies in neonatal resuscitation significantly improve nursing students' knowledge and skill.

Keywords: Neonatal resuscitation, Education, Nursing students, Knowledge, Skill