ABSTRACT

Background: In most cases, hepatitis C progresses gradually to chronic disease.Clotting profile has been integral part of comprehensive assessment of patients presenting with liver impairment. We studied variation of PT, APTT with Fibroscan score in determining stages of fibrosis.

Methods: The retro-prospective cross sectional study was carried out at LGH, Lahore from February 14, 2018 to January 14, 2019. We studoed on 260HCV infected patients, patients having coagulationpathologies other than liver impairment were excluded.Patients were assessed for PT, APTTand fibrosisstage was determined by Fibroscan score. To determine the significant association between continuous variables and liver fibrosis stages, Spearman’s rank correlation was used.

Results: For stage F0-F1 and F2, PT and APTT variables showed non- significant relationship (p >0.05) while for stage F3 and F4, significant relationship with found with p=0.022 and p=0.01 respectively

Conclusion: PT, APTT can be used as prognostic markers efficiently only at stages of advanced fibrosis and cirrhosiswhile initial stages of fibrosis don’t affect PT, APTT significantly. Implication of study can be limited by pathological factors other than liver disease in individual cases.