ABSTRACT

Aim: To evaluate the medical management of second trimester miscarriage with misoprostol

Methodology: A study was performed conducted at obstetrics and gynecology unit A, Mardan Medical Complex Hospital, Mardan from Dec. 2018 to Oct. 2019.

Sample size: Hundred women with 2nd trimester pregnancy loss were included. Age ranges from 16 to 45 years and parity ranges from zero to para five. Ethical approval has been taken from ethical committee.

Results: The use of misoprostol in 2nd trimester miscarriages resulted in 100% success rate. Mean induction to expulsion interval was 18 hrs. Toxic effects noted were pain, pyrexia, nausea, vomiting and diarrhea and are reversible. There is no relationship between parity and response to misoprostol. In this study, anencephalies, hydrocephalies, intrauterine fetal deaths were 30, 28, and 30 respectively. More than one side effect was noted in 14 patients. Treatment of 2nd trimester pregnancy loss with misoprostol is efficient, acceptable and cost effective.

Conclusion: Misoprostol is associated with high success rate within 48 hrs of first dose.

Key words: Misoprostol, Miscarriage, Intrauterine Fetal Death