ABSTRACT

Aim: To evaluate potential effects of Almonds (Prunus Amygdalis) on sperm morphology as such and after administration of Atenolol. Methods: This laboratory-based randomized control trial was conducted out in the Physiology Department, Shifa College of Medicine, Islamabad. The Laboratory of Shifa International Hospital, Islamabad and CREAM lab of Army Medical College, Rawalpindi collaborated in this study from December, 2015 to July, 2016 on 120 Balb C mice. Animals were divided into four groups (n=30). Animals in group A(Control) were given 1 cc water and 1cc DMSO(Atenolol solvent). Group B mice were givenAtenolol 18 mg/Kg body weight/ml of DMSO, group C mice were given almonds extract 100mg/Kg. Group D mice (n=30) were given Atenolol 18 mg/Kg body weight/ml of DMSO, andalmond extract 100 mg/Kg, these agents were administered orally once daily for 3 months. After

Results: Percentage of abnormal sperms was 1.580% ± 0.67% in-group A(control). Therewas significant increase in-group B (Atenolol) to 13.762% ± 5.31%. In-group C(Almond) it decreased to 1.242% ± 0.76% and in-group D(Atenolol+Almond) it was increased to 1.615 ± 0.96% as compared to group A but not significantly.

Conclusion: Prunus Amygdalis not only has beneficial effects on sperm morphology innormal mice but can also reverse atenolol-induced abnormalities.

Keywords: Atenolol, Almonds, Prunus Amygdalis, Sperm Morphology, Balb C mice.