ABSTRACT

This study included the preparation and spectroscopy of the new Schiff base, as a two-step Schiff base was prepared, the first of the reaction of 4-nitro-acetophenone with terephthalaldehyde. The second step is the reaction of 2-aminothiazole with the product of the first reaction. The compound was diagnosed using spectroscopic methods that included an IR Spectra, 1H-NMRspectra and a mass spectra, and the results were practically identical to expectations.

Lethal dose was determined to half (LD50) for Schiff base after they were dissolved with DMSO, and then the safe therapeutic dose was calculated, which was 0.18 g/ kg.

This compound was dosed orally as a therapeutic dose for a group of male rats, after they were infected with hydatid cysts. To find out the therapeutic efficacy of it on the hydatid cysts, and to compare it with a group that was infected with the same disease and treated with Albendazole, the dosing period lasted 30 days for each of the above groups.

The results of the Field Emission Scanning Electron Microscope (FE-SEM)study of the hydatid cysts of the positive control group showed that the hydatid cyst contains aGerminal Layer (GL) and contains large numbers of Protoscolices. Also, in the infected group and treated with the lip base, the presence of cracks and very few Protoscolices in the germinal layer compared to the positive control group, as well as the presence of wrinkles in the hydatid cyst.

Keywords: Echinococcusgranulosus, Schiff base, Chalcone, Electron microscope