ABSTRACT

Aim: To show role of phytase, yeast and Nigella sativaon the liver of male rat.

Methods: 25 adult male rats were used in this study and divided into five groups (5 rats each group); control group. second group: rat feeding with special diet content (50mg/kg) phytase for four weeks. Third group: rat feeding with special diet content (25mg/kg) phytase and (50mg/kg) yeast for four weeks. Fourth group: rat feeding with special diet content (25mg/kg) phytase and (25mg/kg) yeast for four weeks. Fifth group: rat administrated with Nigella sativa (100mg/kg) extract for four weeks.

Results: Histological study of control group section show normal form of hepatocytes and central vein with normal size of sinusoids. the section of (50mg/kg) phytase group show no difference between this group and control group. The sections of (25mg/kg) phytase and (50mg/kg) yeast group and (25mg/kg) phytase and (25mg/kg) yeast also show no difference between these groups and control group. Section of Nigella sativa (100mg/kg) extract show no difference between this group and control group.

Conclusion: It was concluded that phytase, yeast and Nigella sativahas been good effect on the liver tissue of male rat.

Keywords: Phytase enzyme; Yeast: Nigella sativa; Liver tissue; Rat